Dutch Lipid Clinic Network Score
perekondliku hüperkolesteroleemia (FH) diagnoosimiseks
| Criteria |
Points |
| Family history |
|
| First-degree relative with known premature* coronary and vascular disease, OR 1 First-degree relative with known LDL-C level above the 95th percentile |
1 |
| First-degree relative with tendinous xanthomata and/or arcus cornealis, OR 2 Children aged less than 18 years with LDL-C level above the 95th percentile |
2 |
| Clinical history |
|
| Patient with premature* coronary artery disease |
2 |
| Patient with premature* cerebral or peripheral vascular disease |
1 |
| Physical examination |
|
| Tendinous xanthomata |
6 |
| Arcus cornealis prior to age 45 years |
4 |
| Cholesterol levels mg/dl (mmol/liter) |
|
| LDL-C >= 330 mg/dL ( ≥8.5) |
8 |
| LDL-C 250 – 329 mg/dL (6.5–8.4) |
5 |
| LDL-C 190 – 249 mg/dL (5.0–6.4) |
3 |
| LDL-C 155 – 189 mg/dL (4.0–4.9) |
1 |
| DNA analysis |
|
| Functional mutation in the LDLR, apo B or PCSK9 gene |
8 |
| Diagnosis (diagnosis is based on the total number of points obtained) |
Total |
| Definite Familial Hypercholesterolemia |
>8 |
| Probable Familial Hypercholesterolemia |
6-8 |
| Possible Familial Hypercholesterolemia |
3-5 |
| Unlikely Familial Hypercholesterolemia |
<3 |
| Result |
0 |
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